RUMC Researcher's Profile
MR. MAHESWARAN SOLAYAPPAN
BSC (HONS) IN BIOTECHNOLOGY (2009), AIMST UNIVERSITY
Mr Mahes research highlights focuses on the role of Tribbles genes, in various aspects of eukaryotic cell biology, with a focus on their implication in acute myeloid leukemia. TRIB is a pseudo serine/threonine kinase that acts as a scaffold or adaptor in both physiological and pathological processes.
It plays a crucial role in the degradation of C/EBPα and C/EBPβ, proteins involved in cell cycle arrest and myeloid differentiation. The study utilizes the CRISPR Cas-9 system to knockdown the TRIB 2 gene in Acute Myeloid Leukemia (AML) to investigate the differential expression of C/EBPα.
This approach highlights TRIB’s potential as a pathogenic mechanism in a subset of human AML, where its overexpression leads to the destabilization of C/EBPα through proteasome-dependent degradation, thereby opposing the effects of C/EBPα on myeloid cell differentiation.
COLLABORATION NETWORK
- Prof. Dr. M. Ravichandran, Chief Scientific Officer (CSO), MyGenome Sdn. Bhd.
- Assoc. Prof. Dr. Vinod RMT, Jeffrey Cheah School of Medicine and Health Sciences, Monash University
- Dr. Emmanuel J. Moses, Advanced Medical & Dental Institute, USM
- Prof. Dr. Lee Su Yin, Faculty of Applied Sciences, AIMST University
- Dr. Foo Kai Loong, Nano Biochip Research Group, Institute of Nano Electronic Engineering (INEE), Universiti Malaysia Perlis (UniMAP)
- MEMBER – ORGAN-ON-A-CHIP TECHNOLOGIES NETWORK, UK
- MEMBER – MALAYSIAN BOARD OF TECHNOLOGIST (MBOT)
Research Interest
TRIBBLES PSEUDOKINASE GENES (TRIB1, 2 & 3)
CRISPR GENE EDITINGCANCER RESEARCH
BIOSENSOR-BASED RESEARCH FOR EARLY DISEASE DETECTION
Current Research Interest
Awards & Recognition
| Award | Years |
|---|---|
| ASEAN-India Research Training Fellowship | 2023 |
| World Federation of Scientists (WFS) Scholarship | 2010 |
| 2nd Place in National Postgraduate Research Poster Competition | 2010 |
Publications
2024-JOURNALS
- Keya, Tahmina A.; Sreeramanan, S1; Siventhiran, S B2; Maheswaran, S3; Selvan, Saravana4; Fernandez, Kevin; An, Low J5; Leela, A6; Prahankumar, R7; Lokeshmaran, A8; Boratne, AV9. Flood Susceptibility Mapping for Kedah State, Malaysia: Geographics Information System-Based Machine Learning Approach. Medical Journal of Dr. D.Y. Patil Vidyapeeth ():10.4103/mjdrdypu.mjdrdypu_985_23, June 25, 2024. | DOI: 10.4103/mjdrdypu.mjdrdypu_985_23
- Mahendran, T. R., Cynthia, B., Thevendran, R., & Maheswaran, S. (2024). Prospects of Innovative Therapeutics in Combating the COVID-19 Pandemic. Molecular Biotechnology, 1-9.
- Ugrappa, S., Jagadeesan, D., Lalitha, P., Ravichandran, M., Solyappan, M., Khor, G., Fuloria, S. (2024). Synthesis, Characterization, Docking Studies and in vitro Response of New Camptothecin Derivatives towards Oral Squamous Cell Carcinoma. Asian Journal of Chemistry, 36(3), 731–739. https://doi.org/10.14233/ajchem.2024.31038
- Jaafar Mohamad Hafis, Xu Pei, Mageswaran Uma-Mageswary, Balasubramaniam Shandra-Devi, Solayappan Maheswaran, Woon Jia-Jie, Teh Cindy Shuan-Ju, Todorov Svetoslav Dimitrov, Park Yong-Ha, Liu Guoxia, Liong Min-Tze. Constipation anti-aging effects by dairy-based lactic acid bacteria. J Anim Sci Technol 2024;66(1):178-203. https://doi.org/10.5187/jast.2023.e93
2023-JOURNALS
- Mahendran, T.R., Cynthia, B., Maheswaran, S., Manickavasagam, G. et al. Isolation and evaluation of antiviral plant compounds against respiratory disease-causing viruses: a review. ADV TRADIT MED (ADTM)(2023). https://doi.org/10.1007/s13596-023-00723-0
- Haarindraprasad, R. P., Thurga Devi, N., Thevendran, R., & Maheswaran, S. (2023). Spiked nanorosette: A novel zinc oxide‐gold textured nanostructure for impedance biosensing of target DNA signatures. Biotechnology Journal, 18(8), 2300092.
- Selvan, S., Meng, L. K., Zaman, M., Solayappan, M., Nair, P., & Kumar, D. (2023, December). Design and Performance Analysis of Dielectric Modulated MoTe 2 Junction-less Tunnel FET based biosensor. In 2023 IEEE 8th International Conference on Recent Advances and Innovations in Engineering (ICRAIE) (pp. 1-6). IEEE.
Funded Projects
- ASEAN-India Research Training Fellowship (2024) – Studying CRISPR-induced knockout of Tribbles gene in zebrafish for AML treatment
- Fundamental Research Grant Scheme (FRGS) (2023) Developing a live-attenuated Dengue vaccine candidate (RM 156,100)
- Research Collaboration Agreement (2023) – In vitro human erythrocyte differentiation study (RM 31,000)
- FRGS (2022) – Molybdenum Telluride-based biosensor for biomolecule detection (RM 137,000)
- FRGS (2019) – Differential expression of TRIB genes in AML via CRISPR (RM 118,000)
- FRGS (2014) – HPV-mediated loss of Nuclear Receptor Co-Repressor in cervical cancer (RM 142,400)
Information is correct at time of printing / publication. RUMC reserves the right to amend the information without prior notice.